SMAC-Technology:
Beerli, R. R., Hell, T., Merkel, A., and Grawunder, U. (2015) Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency. PLoS ONE 10, e0131177.
Published: July 2015
Highly potent PNU payload:
Stefan, N., Gébleux, R., Waldmeier, L., Hell, T., Escher, M., Wolter., F. I., Grawunder, U., & Beerli, R. R. (2017) Highly potent, anthracycline-based antibody drug conjugates generated by enzymatic, site-specific conjugation. Mol Cancer Ther 16, 879-892.
Published: May 2017
IO function of NBE's PNU payload:
D’Amico, L., Menzel, U., Prummer, M., Buchi, M., Müller, P., Kashyap, A., Haessler, U., Yermanos, A., Gébleux, R., Briendl, M., Hell, M., Wolter, F. I., Beerli, R. R., Truxova, I Radek, S., Tatjana, V., Grawunder, U., Reddy, S., & Zippelius, A. (2019) A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer. J. Imm. Ther. Cancer 7: 16
Published: January 2019
ROR1 prevalence
Raso, M. G., Barrientos Toro, E., Evans, K., Rizvi, Y., Lazcano, R., Akcakanat, A., Sini, P., Trapani, F., Madlener, E. J., Waldmeier, L., Lazar, A., & Meric-Bernstam, F. (2024). Heterogeneous Profile of ROR1 Protein Expression across Tumor Types. Cancers, 16(10), 1874. https://doi.org/10.3390/cancers16101874
Published: 15 May 2024
Silva, M.A., Williams, S., Hauert, S., Ovadia, B., Gupta, I., Waldmeier, L., Jaimes, Y., and Al-Masri, H. (2024) Tumour assessment of ROR1 levels in various adult leukaemia and lymphoma types. PLoS One 11, e0313026.
Published: November 2024
Transpo-Mab antibody discovery platform:
Hellmann, I., Waldmeier, L., Bannwarth-Escher, M., Maslova, K., Wolter, F. I., Grawunder, U. & Beerli, R. R. (2008) Novel antibody drug conjugates targeting tumor-associated receptor tyrosine kinase ROR2 by functional screening of fully human antibody libraries using Transpo-mAb display on progenitor B cells. (2018) Front. Immunol. 9, 2490.
Published: November 2018
Waldmeier, L., Hellmann, I., Gutknecht, C. K., Wolter, F. I., Cook, S. K., Reddy, S. T., Grawunder, U. & Beerli, R. R. (2016) Transpo-mAb Display: transposition-mediated B cell display and functional screening of full-length IgG antibody libraries. mAbs 8, 726-740.
Published: April 2016
ROR1 antibody discovery and ROR1 prevalence:
Peng, H., Nerreter, T., Chang, J., Qi, J., Li, X., Karunadharma, P., Martinez, G., Fallahi, M., Soden, J., Freeth, J., Beerli, R. R., Grawunder, U., Hudecek, M., & Rader, C. (2017) Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility. J. Mol. Biol. 429, 2954–2973.
Published: September 2017
PNU – Mode of Action
Kaiser, M., Fiedler, U., Popa, A., Gerlach, D., Kraut, N. and Bammert, L. (2024) The ADC payload PNU-159682 is highly active in a wide range of cancer indications by inducing DNA damage and cell death via a distinct mode of action. Poster presented at AACR 2024, San Diego, CA.
Presented April 2024
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