PNU anthracycline payload
Technology
PNU
Technology
PNU anthracycline payload
PNU-159682, the active metabolite of Nemorubicin, is a highly potent anthracycline derivative.
Its mode of action is driven by interfering with the DNA of cancer cells, preventing them from dividing and growing. The PNU derivative shows excellent properties as an ADC payloads and induces immunogenic cell death (iADC).
PNU ADCs allow to address low expressing antigen targets not in reach for other payload classes, thereby opening the target space for ADCs in general.
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