Research Assistant (Biochemistry)

NBE-Therapeutics is a subsidiary of the Boehringer Ingelheim group: a perfect symbiosis between a rapidly growing biotechnology company and an already well-established big pharma. We are located in Basel, a Swiss city on the river Rhine, known for being an important center of chemical and pharmaceutical industries and renowned for its versatile cultural aspects – a great place to live and work. Our research team is committed to the development of next generation antibody drug conjugates (ADCs) for cancer patients in need for new transformational treatments.

We are looking for a highly motivated:

Research Assistant (Biochemistry)

Job Description

You will support the generation and characterization of novel ADCs for pre-clinical evaluation in relevant in vitro and in vivo cancer models. As the team is still expanding, we are looking for a motivated and self-dependent team player, who likes to work in a dynamic environment where everyone’s performance has an impact on the success of the program and who likes to be part of the team supporting the company’s further growth.

Your Profile

• Laboratory Technician with an Apprenticeship and/or BSc in Biochemistry, Chemistry, Biology or related discipline. Applications sent by candidates holding a MSc or PhD degree will not be considered for this open position.
• work experience and/or a track record of analytical characterization of biologics, such as IgG, peptides and/or glycans is an asset
• Knowledge in standard biochemical methods (UV-VIS, Protein A/StrepTactin purification, Desalting, Endotoxin Assay and ELISA based assays)
• Interest in HPLC-based analytics of biologics and/or small molecules is key (Reversed Phase-, Size Exclusion-, Hydrophobic Interaction-Chromatography and Massspectrometry)
• Agile person showing eagerness to familiarize with new techniques and devices, and interest in finding the best solutions to solve a problem
• Team player with good communication skills, able to interact well with a small team, but also skilled to work independently
• Diligent and respectful with regard to general lab processes and organization
• Residence in Basel or surrounding is key to flexibility and company success
• Good knowledge of English (written and spoken) is a prerequisite, German is helpful but not essential

Your Responsibilities

• Support development of novel cancer drugs and therapeutic approaches
• Conducting of small scale manufacturing of ADCs with proprietary enzymatic ADC conjugation platfrom (SMAC™-Technology) for evaluation in cellular assays and in vivo studies according existing protocols
• Further development of the ADC conjugation platform with the Team Conjugation
• Application of existing HPLC-based analytical methods for ADC characterization (RP,SEC,HIC and MS)
• Biochemical characterization of ADCs with the named methods
• Independent planning, and coordination of experiments including data analysis and accurate documentation of data in electronic laboratory notebooks
• Support preparation of reports, manuscripts, and meeting presentations

Who We Are And Our Culture

NBE-Therapeutics is an equal opportunity employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment, which benefits our employees, patients and communities.

In 2021, NBE Therapeutics joined as a subsidiary specialized in ADCs, the Boehringer Ingelheim group which focuses on innovative medicines for people and animals since more than 130 years. Boehringer Ingelheim is one of the pharmaceutical industry’s top 20 companies and to this day remains family-owned. Day by day, some 50’000 employees create value through innovation for the three business areas human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. In 2017, Boehringer Ingelheim achieved net sales of nearly 18.1 billion euros. R&D expenditure, exceeding 3 billion euros, corresponded to 17.0 per cent of net sales.

At NBE-Therapeutics, we offer a permanent position in a young, dynamic and science driven work environment, providing opportunities for learning and development, because your personal growth is our growth. We work in cross-functional teams across different sites sharing our common goal to transform our patients lives.

We look forward to receiving your application including a motivation letter, which you are resnbejobs.bas@boehringer-ingelheim.com referring to job-opening: Ref220304j-RA/C1